Pathways
G1-S Phase Transition
Description:
Cell cycle arrest in response to DNA damage is an important mechanism for maintaining genomic integrity. This cell cycle arrest provides time for DNA repair to prevent replication or segregation of damaged DNA. Induction of growth arrest by DNA damage occurs mainly through the activation of checkpoint pathways that delay cell cycle progression at G1, S, and G2 (Ref.1 and 2).
In vertebrate cells, the commitment to complete a round of mitotic division takes place during the initial phase of the cell cycle (G1), at a ...
References:
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p53 and cell cycle effects after DNA damage.
Methods Mol Biol. 2013;962:49-61. doi: 10.1007/978-1-62703-236-0_4. -
The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle.
J Cell Sci. 2015 Feb 15;128(4):607-20. doi: 10.1242/jcs.163766. Epub 2015 Jan 20. Review. -
Control of cell cycle transcription during G1 and S phases.
Nat Rev Mol Cell Biol. 2013 Aug;14(8):518-28. doi: 10.1038/nrm3629. Review. -
Cell-context specific role of the E2F/Rb pathway in development and disease.
Glia. 2010 Mar;58(4):377-90. doi: 10.1002/glia.20933. Review.
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